High Performance Omega PES Membrane Combined with Significant Material and Design Improvements Deliver Highly Reliable Fluid Dynamics and Better Process Economics
Easy implementation into your process. The new T-series cassettes offer significant improvements in construction and design while utilizing the same proven Omega polyethersulfone (PES) membrane to reduce revalidation requirements.
Increased safety, reliability, and reproducibility. Superior new materials of construction are durable and stable, exhibit very low extractables, and offer broad chemical compatibility.
High flux, high selectivity, and low protein binding are achieved through the use of Omega PES membrane.
Improved process performance. Cassettes are designed to provide optimal mass transfer to improve your process economics.
Easy scale up for robust purification processes. Available in scalable formats with the same materials of construction from development to production-scale processes.
Enhanced validation. T-series cassettes surpass the latest biopharmaceutical and regulatory standards such as biological reactivity, extractables, and TOC. Product claims are backed by extensive validation documentation to support the use of T-Series cassettes in your process.
Proven Omega Membrane
Pall의 Omega PES(polyethersulfone) 멤브레인은 높은 유량과 선택성을 제공합니다. 해당 멤브레인은 멤브레인의 표면 및 사이 구조에서 단백질 결합을 최소화하도록 수정되었습니다. 이 고분자 멤브레인은 PES의 독특한 화학적 특성으로 인해 생물적 및 물리적 분해가 잘 되지 않습니다.
Omega 멤브레인은 다공성이 높은 부직포 폴리올레핀 지지대 위에 주조되어 있습니다. 이 멤브레인은 다공성이 높은 하부 지지대 위에 얇은 외피형의 상층부가 있는 이방성 구조를 지닙니다. 이 외피 구조가 다공성 및 투과성의 멤브레인 특성을 결정하며, 1마이크론 미만의 균일한 구조의 멤브레인보다 일반적으로 세정이 빠르고 용이할 수 있습니다. 이 멤브레인은 산, 염기 세제 및 그 밖의 다양한 세제를 사용할 수 있습니다. Omega 멤브레인은 광범위한 NMWCO(공칭 분자량 차단)에 사용할 수 있습니다.
The T-Series Advantage
Superior new materials of construction and improved cassette design increase process safety, reliability, reproducibility, and productivity:
The feed and permeate screen material for T-Series cassettes is made from polypropylene which is highly resistant to sodium hydroxide.
Larger feed and permeate ports provide lower pressure drops.
T-Series cassettes have been designed to provide maximum mass transfer through the membrane, resulting in faster processing times or reduced area installations compared to existing similar cassette formats.
T-Series cassettes with Omega membrane are designed for development, pilot, and production-scale TFF applications in diverse biological and biopharmaceutical processes. They are especially useful in:
Vaccine and conjugate concentration and diafiltration
Purification and recovery of monoclonal antibodies (mAb) or recombinant proteins
혈장 분획 및 정제
T-Series cassettes complement Pall’s highly successful Centramate™ and Centrasette™ products, and have been developed following years of experience designing and optimizing our customers’ biotech and biopharmaceutical processes.
T-Series cassettes for Centramate holders are offered in scalable membrane formats with effective filtration areas (EFA) from as low as 200 cm2 (0.215 ft2) to 0.5 m2 (5.4 ft2), making them ideal for process development and small-scale production of 0.1 L to 125 L. Centrasette T-Series cassettes, in combination with Centrasette holders, can process thousands of liters with installations incorporating hundreds of square meters of EFA.
1Pressure rating will be dependant on rating of the lowest system component. 2Cassettes must not be allowed to freeze.
Typical Operating Parameters
Cross Flow Rate for Processing
5 – 7 L/min/m2 (0.5 – 0.7 L/min/ft2)
Cross Flow Rate for Cleaning
8 – 10 L/min/m2 (0.8 – 1.0 L/min/ft2)
2 barg (30 psig)
Maximum Air Forward Flow
< 1600 sccm/m2 (< 150 sccm/ft2)
The shelf life of cassettes packaged in 0.3 N sodium hydroxide is expected to be three years from the date of manufacture when the cassettes are stored unopened in the original packaging at 4 – 25 °C and protected from direct light. Extended shelf life studies are ongoing.
All of the materials of construction in the T-Series cassettes have been tested and meet requirements for United States Pharmacopeia (USP) Biological Reactivity Test, In Vivo <88> at 70 °C.
Omega 10 kD Membrane, Centramate C vs. T-Series Membrane Cassettes at a 5 L/min/m2Cross Flow Rate
Each T-Series membrane cassette has a unique serial number for full traceability. Each cassette is supplied with:
Certificate of Quality
Membrane Cassette Care and Use Procedures
Material Safety Data Sheet (MSDS) for cassette preservative
Two platinum cured silicone gaskets
The full Validation Guide is available on request from your local Pall contact. Pall also offers a comprehensive Validation Service for specific tests (such as compatibility) in your process fluid. As always, Pall’s Downstream Processing Specialists are available to train and support you in the optimization of your TFF processes.
To test T-Series cassettes in your process, contact Pall today.
Omega Low Protein Binding Modified Polyethersulfone Membrane
Type and Area Screen Channel
Centramate 0.02 m2 (0.2 ft2)
Centramate 0.1 m2 (1.1 ft2)
Centrasette 0.5 m2 (5.4 ft2)
Centrasette 2.5 m2 (27 ft2)
*Select Nominal Molecular Weight Cutoff (NMWC) from table below and insert corresponding code number, for example, part number OS010T12 is an Omega Membrane, 10 kD NMWC, Centramate 0.1 m2 (1.1 ft2) screen channel cassette.