Low Protein Binding Delta Membrane Used in the Proven T-Series Cassette Design Optimizes Process Economics
Improved process performance. Cassettes are designed to provide optimal mass transfer to improve your process economics.
Increased safety, reliability, and reproducibility. Superior new materials of construction are durable and stable, and exhibit very low extractables. Membrane is backpressure resistant up to 4.1 barg (60 psig).
Easy scale up for robust purification processes. Available in scalable formats with the same materials of construction from development to production-scale processes.
High flux, high selectivity, and low protein binding are achieved through the use of Delta regenerated cellulose membrane.
Delta Regenerated 셀룰로오스 멤브레인
Delta Regenerated 셀룰로스 멤브레인은 높은 유량과 선택성을 제공합니다. 이 멤브레인은 멤브레인의 표면 및 사이 구조에서 단백질 결합을 최소화하도록 특화되어 개발되어 왔습니다. 본질적으로 친수성인 이 멤브레인은 단백질 흡착 특성이 낮기 때문에 친수성이 높은 단백질이 포함된 공정에 적합합니다. Delta Regenerated 셀룰로스 멤브레인은 파울링 특성이 낮기 때문에 생산 가동 중 성능과 유량이 일정합니다. 세정이 용이하며, 일반적으로 0.8N 염류용액만 사용하여 NWP(정규화 투수성)이 회복됩니다.
T-Series Cassettes with Delta Membrane Offer Excellent Scalability Among Formats
T01 93 cm2 (0.1 ft2) EFA
T02 186 cm2 (0.2 ft2) EFA
T12 0.1 m2 (1.1 ft2) EFA
T06 0.5 m2 (5.4 ft2) EFA
T26 2.5 m2 (27 ft2) EFA
The T-Series Advantage
Superior new materials of construction and improved cassette design increase process safety, reliability, reproducibility, and productivity:
The feed and permeate screen material for T-Series cassettes is made from polypropylene which is highly resistant to sodium hydroxide.
Larger feed and permeate ports provide lower pressure drops.
T-Series cassettes have been designed to provide maximum mass transfer through the membrane, resulting in faster processing times or reduced area installations compared to existing similar cassette formats.
To test the new T-Series cassettes with Delta membrane in your process, contact Pall today.
T-Series cassettes with Delta regenerated cellulose membrane are designed for development, pilot, and production-scale TFF applications in diverse biological and biopharmaceutical processes. They are especially useful in:
Antibody fragments (Fab)
Purification and recovery of antibodies
Concentration and diafiltration of recombinant proteins
혈장 분획 및 정제
T-Series cassettes complement Pall’s highly successful Centramate™ and Centrasette™ products, and have been developed following years of experience designing and optimizing our customers’ biotech and biopharmaceutical processes.
T-Series cassettes for Centramate holders are offered in scalable membrane formats with effective filtration areas (EFA) from as low as 93 cm2 (0.1 ft2), making them ideal for process development and small-scale production of 50 mL to 125 L. Centrasette T-Series cassettes, in combination with Centrasette holders, can process thousands of liters with installations incorporating hundreds of square meters of EFA.
1 Pressure rating will be dependant on rating of the lowest system component. 2 Cassettes must not be allowed to freeze.
Typical Operating Parameters
Cross Flow Rate for Processing
5 – 7 L/min/m2 (0.5 – 0.7 L/min/ft2)
Cross Flow Rate for Cleaning
5 – 8 L/min/m2 (0.5 – 0.8 L/min/ft2)
4 barg (60 psig)
Maximum Air Forward Flow
< 500 sccm/m2 (< 50 sccm/ft2)
The shelf life of cassettes packaged in preservative is expected to be three years from the date of manufacture when the cassettes are stored unopened in the original packaging at 4 – 25 °C and protected from direct light. Extended shelf life studies are ongoing.
All of the materials of construction in the T-Series cassettes have been tested and meet requirements for United States Pharmacopeia (USP) Biological Reactivity Test, In Vivo <88> at 70 °C.
Each T-Series membrane cassette has a unique serial number for full traceability. Each cassette is supplied with:
Certificate of Quality
Membrane Cassette Care and Use Procedures
Material Safety Data Sheet (MSDS) for the cassette preservative
Two platinum cured silicone gaskets
The full Validation Guide is available on request from your local Pall contact. Pall also offers a comprehensive Validation Service for specific tests (such as compatibility) in your process fluid. As always, Pall’s Downstream Processing Specialists are available to train and support you in the optimization of your TFF processes.
T-Series Cassettes with Delta Low Protein Binding, Regenerated Cellulose Membrane